High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis

被引：27

作者：

Wu, Yen-Wen ^{[1
,2
,4
]}

Yang, Wei-Shiung ^{[1
,4
]}

Chen, Ming-Fong ^{[1
]}

Lee, Bai-Chin ^{[1
]}

Hung, Chi-Sheng ^{[1
]}

Liu, Yu-Chun ^{[1
]}

Jeng, Jiann-Shing ^{[3
]}

Huang, Por-Jau ^{[1
]}

Kao, Hsien-Li ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Neurol, Taipei 100, Taiwan

[4] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 10764, Taiwan

来源：

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 2008年 / 107卷 / 01期

关键词：

atherosclerosis; carotid plaque; inflammation; matrix metalloproteinase-1;

D O I：

10.1016/S0929-6646(08)60015-7

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

High tissue matrix metalloproteinase (MMP) activity has been reported to be associated with atherosclerosis and plaque rupture. The aim of this study was to elucidate the diagnostic value of serum MMP-1 in carotid stenosis and its dynamic change after stenting. We measured high-sensitivity C-reactive protein (hs-CRP) and MMP-1 in 37 patients with carotid stenosis (>= 50%) and 84 controls. In 30 patients who underwent stenting, MMP-1 and hs-CRP were assessed immediately after stenting. We found that patients with carotid stenosis exhibited significantly higher MMP-1 compared with controls, but there was no difference in hs-CRP. Moreover, MMP-1 was elevated immediately after stenting. In multivariate analyses, MMP-1 was negatively correlated with statin and angiotensin converting enzyme inhibitor/angiotensin-II receptor blocker use in controls. In conclusion, higher levels and rapid surge after stenting in patients with carotid stenosis indicate that MMP-1 is an important composition of plaques, and suggest its potential role in the assessment of plaque burden and stability of carotid stenosis.

引用

页码：93 / 98

页数：6

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