Synthesis, physico-chemical and iron(III)-chelating properties of novel hexadentate 3-hydroxy-2(1H)pyridinone ligands

被引:34
作者
Rai, BL [1 ]
Khodr, H [1 ]
Hider, RC [1 ]
机构
[1] Univ London Kings Coll, Dept Pharm, London SW3 6LX, England
关键词
D O I
10.1016/S0040-4020(98)01091-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Synthesis of hexadentate ligands via the in situ formation of l-hydroxy benzotriazolyl active ester in the presence of 2(1H-benrotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU as a coupling agent is described. The pKa values and distribution coefficient values (1-octanol/water) of the ligands and the stability constants of their iron(III) complexes are reported. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:1129 / 1142
页数:14
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