Molecular determinants of brown adipocyte formation and function

被引：144

作者：

Farmer, Stephen R. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 10期

关键词：

PRDM16; adipogenesis; CtBP; PGC-1; PPAR-gamma; resistin;

D O I：

10.1101/gad.1681308

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397-1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPAR gamma coactivator-1 alpha (PGC-1 alpha) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.

引用

页码：1269 / 1275

页数：7

共 44 条

[1] Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation [J].

Arany, Zoltan ;

Wagner, Bridget K. ;

Ma, Yanhong ;

Chinsomboon, Jessica ;

Laznik, Dina ;

Spiegelman, Bruce M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4721-4726

[2] HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α [J].

Arany, Zoltan ;

Foo, Shi-Yin ;

Ma, Yanhong ;

Ruas, Jorge L. ;

Bommi-Reddy, Archana ;

Girnun, Geoffrey ;

Cooper, Marcus ;

Laznik, Dina ;

Chinsomboon, Jessica ;

Rangwala, Shamina M. ;

Baek, Kwan Hyuck ;

Rosenzweig, Anthony ;

Spiegelman, Bruce M. .

NATURE, 2008, 451 (7181) :1008-U8

[3] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[4] Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery induced weight loss [J].

Cancello, R ;

Henegar, C ;

Viguerie, N ;

Taleb, S ;

Poitou, C ;

Rouault, C ;

Coupaye, M ;

Pelloux, V ;

Hugol, D ;

Bouillot, JL ;

Bouloumié, A ;

Barbatelli, G ;

Cinti, S ;

Svensson, PA ;

Barsh, GS ;

Zucker, JD ;

Basdevant, A ;

Langin, D ;

Clément, K .

DIABETES, 2005, 54 (08) :2277-2286

[5] Brown adipose tissue: Function and physiological significance [J].

Cannon, B ;

Nedergaard, J .

PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359

[6] Peroxisome proliferator-activated receptor γ agonists inhibit adipocyte expression of α1-acid glycoprotein [J].

Castriota, Gino ;

Thompson, G. Marie ;

Lin, Ying ;

Scherer, Philipp E. ;

Moller, David E. ;

Berger, Joel P. .

CELL BIOLOGY INTERNATIONAL, 2007, 31 (06) :586-591

[7] Transcriptional regulation by C-terminal binding proteins [J].

Chinnadurai, G. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (09) :1593-1607

[8] Metabolic regulation by the nuclear receptor corepressor RIP140 [J].

Christian, Mark ;

White, Roger ;

Parker, Malcolm G. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2006, 17 (06) :243-250

[9] Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARγ [J].

do Nascimento, CO ;

Hunter, L ;

Trayhurn, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (03) :702-708

[10] Physiology and pathophysiology of the adipose tissue renin-angiotensin system [J].

Engeli, S ;

Negrel, R ;

Sharma, AM .

HYPERTENSION, 2000, 35 (06) :1270-1277

← 1 2 3 4 5 →