Role of IL-18 in the secretion of IL-1β, sIL-1rII, and IL-1Ra by human neutrophils

被引：10

作者：

Jablonska, E

Izycka, A

Jablonski, J

Wawrusiewicz, N

Piecuch, J

机构：

[1] Med Acad Bialystok, Dept Immunopathol, PL-15230 Bialystok 8, Poland

[2] Med Acad Bialystok, Dept Toxicol, PL-15230 Bialystok, Poland

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2001年 / 30卷 / 03期

关键词：

neutrophils; interleukin-18; interleukin-1; beta; soluble interleukin-1 receptor II; interleukin-1 receptor antagonist;

D O I：

10.1081/IMM-100105066

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the present study we investigated the effect of IL-18 on the production of IL-1 beta, IL-1Ra and sIL-1RII by human neutrophils. Our observations indicate that rhIL-18 induces IL-1 beta and, to a lesser extend, IL-1Ra and sIL-1RII production by human neutrophils isolated form peripheral blood. However. this effect was less important in comparison with LPS-stimulation. Moreover, the results obtained suggest that IL-18 can induce priming of neutrophils for IL-1 beta and, to a lesser extend, IL-1Ra and sIL-1RII production by LPS-stimulated cells. The capacity of IL-18 to serve as an effective modulator for IL-1 beta and its regulatory proteins may have significance in the inflammatory and immune reactions mediated by IL-1 beta.

引用

页码：221 / 229

页数：9

共 20 条

[1] Increased interleukin-1 (IL-1) and imbalance between IL-1 and IL-1 receptor antagonist during acute inflammation in experimental shigellosis [J].