Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs

被引:21
作者
Baptista, T
Alvarez, L
Lacruz, A
De Mendoza, S
Hernández, L
机构
[1] Univ Los Andes, Sch Med, Dept Physiol & Psychiat, Merida, Venezuela
[2] Metab Ctr, Merida, Venezuela
关键词
antipsychotic drugs; glucose; insulin sensitivity; obesity; prolactin; rats;
D O I
10.1016/S0278-5846(98)00096-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. To assess the role of insulin in the development of the obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in female rats after 10 or 30 days of sulpiride administration. 2. At day 10, the area under the glucose curve did not differ between sulpiride and vehicle-treated rats, however, the area under the insulin curve was significantly decreased by sulpiride. At day, 30 the insulin response was similar in both groups, but the area under the glucose curve was significantly lower in the sulpiride-treated rats. 3. The results suggest that insulin resistance and hyperinsulinemia are not involved in the development and maintenance of the obesity induced by sulpiride. Contrarily, these findings may be related to an increased insulin sensitivity. 4. The absence of hyperinsulinemia and insulin resistance indicates important differences between primary obesity in humans and rodents and this model of drug-induced excessive weight gain.
引用
收藏
页码:277 / 287
页数:11
相关论文
共 32 条
[1]  
AMMON HPT, 1973, J PHARMACOL EXP THER, V187, P423
[2]   Amantadine in the treatment of neuroleptic-induced obesity in rats: Behavioral, endocrine and neurochemical correlates [J].
Baptista, T ;
Lopez, ME ;
Teneud, L ;
Contreras, Q ;
Alastre, T ;
deQuijada, M ;
deBaptista, EA ;
Alternus, M ;
Weiss, SRB ;
Musseo, E ;
Paez, X ;
Hernandez, L .
PHARMACOPSYCHIATRY, 1997, 30 (02) :43-54
[4]   SYSTEMIC SULPIRIDE INCREASES DOPAMINE METABOLITES IN THE LATERAL HYPOTHALAMUS [J].
BAPTISTA, T ;
HERNANDEZ, L ;
HOEBEL, BG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (02) :227-229
[5]   MECHANISM OF THE SEX-DEPENDENT EFFECT OF LITHIUM ON BODY-WEIGHT IN RATS [J].
BAPTISTA, T ;
MURZI, E ;
HERNANDEZ, L ;
BURGUERA, JL ;
BURGUERA, M ;
BURGUERA, M .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1991, 38 (03) :533-537
[6]   Mechanism of the neuroleptic-induced obesity in female rats [J].
Baptista, T ;
Contreras, Q ;
Teneud, L ;
Albornoz, MA ;
Acosta, A ;
Paez, X ;
de Quijada, M ;
Lacruz, A ;
Hernandez, L .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1998, 22 (01) :187-198
[7]   PUBERTY MODIFIES SULPIRIDE EFFECTS ON BODY-WEIGHT IN RATS [J].
BAPTISTA, T ;
PARADA, MA ;
MURZI, E .
NEUROSCIENCE LETTERS, 1988, 92 (02) :161-164
[8]   ENHANCEMENT OF AMPHETAMINE ANOREXIA AFTER CHRONIC ADMINISTRATION OF SULPIRIDE IN RATS [J].
BAPTISTA, T ;
TENEUD, L ;
HERNANDEZ, L .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 45 (01) :45-49
[9]   Tamoxifen prevents sulpiride-induced weight gain in female rats [J].
Baptista, T ;
DeBaptista, EA ;
Hernandez, L ;
Altemus, M ;
Weiss, SR .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 57 (1-2) :215-222
[10]   LONG-TERM ADMINISTRATION OF SOME ANTIPSYCHOTIC-DRUGS INCREASES BODY-WEIGHT AND FEEDING IN RATS - ARE D2 DOPAMINE-RECEPTORS INVOLVED [J].
BAPTISTA, T ;
PARADA, M ;
HERNANDEZ, L .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (03) :399-405