Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction

被引：65

作者：

Bunte, M. C. ^{[2
]}

Patnaik, M. M. ^{[2
]}

Pritzker, M. R. ^{[2
,3
]}

Burns, L. J. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Div Cardiol, Minneapolis, MN 55455 USA

来源：

BONE MARROW TRANSPLANTATION | 2008年 / 41卷 / 08期

关键词：

pulmonary veno-occlusive disease; endothelial dysfunction; hematopoietic stem cell transplant; defibrotide;

D O I：

10.1038/sj.bmt.1705990

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Veno-occlusive disease is among the most serious complications following hematopoietic stem cell transplantation. While hepatic veno-occlusive disease occurs more commonly, the pulmonary variant remains quite rare and often goes unrecognized antemortem. Endothelial damage may represent the pathophysiologic foundation of these clinical syndromes. Recent advances in the treatment of hepatic veno-occlusive disease may have application to its pulmonary counterpart.

引用

页码：677 / 686

页数：10

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