Routes, destinations and delays: recent advances in AMPA receptor trafficking

被引：121

作者：

Henley, Jeremy M. ^{[1
]}

Barker, Ellen A. ^{[1
]}

Glebov, Oleg O. ^{[1
]}

机构：

[1] Univ Bristol, MRC, Ctr Synapt Plast, Sch Biochem, Bristol BS8 1TD, Avon, England

来源：

TRENDS IN NEUROSCIENCES | 2011年 / 34卷 / 05期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金; 欧洲研究理事会;

关键词：

LONG-TERM POTENTIATION; ACTIVITY-DEPENDENT REGULATION; SYNAPTIC PLASTICITY; PKM-ZETA; PHOSPHORYLATION SITE; GLUTAMATE RECEPTORS; AUXILIARY SUBUNITS; PRION PROTEIN; GLUR2; SUBUNIT; CELL BIOLOGY;

D O I：

10.1016/j.tins.2011.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postsynaptic AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission and are crucial for many aspects of brain function, including learning, memory and cognition. The number, synaptic localization and subunit composition of synaptic AMPARs are tightly regulated by network activity and by the history of activity at individual synapses. Furthermore, aberrant AMPAR trafficking is implicated in neurodegenerative diseases. AMPARs therefore represent a prime target for drug development and the mechanisms that control their synaptic delivery, retention and removal are the subject of extensive research. Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies.

引用

页码：258 / 268

页数：11

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