The neuropeptide YY1 receptor selective radioligand, [I-125][Leu(31),Pro(34)]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors

被引:24
作者
Gehlert, DR [1 ]
Gackenheimer, SL [1 ]
Schober, DA [1 ]
Beavers, L [1 ]
Gadski, R [1 ]
Burnett, JP [1 ]
Mayne, N [1 ]
Lundell, I [1 ]
Larhammar, D [1 ]
机构
[1] UPPSALA UNIV,DEPT MED PHARMACOL,S-75124 UPPSALA,SWEDEN
关键词
neuropeptide Y; pancreatic polypeptide; peptide YY; Leu(31); Pro(34)]peptide YY;
D O I
10.1016/S0014-2999(96)00797-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A number of receptors for the pancreatic polypeptide-fold peptides are proposed based on findings from pharmacology and molecular biology studies. Neuropeptide Y and peptide YY have similar affinity for neuropeptide Y Y-1 and neuropeptide Y Y-2 while pancreatic polypeptide has highest affinity for pancreatic polypeptide 1. Pro(34)-substituted analogs of neuropeptide Y and peptide YY have selectivity for neuropeptide Y Y-1 over neuropeptide Y Y-2 receptors. In the present study, we found that one such 'neuropeptide Y Y-1-selective' radioligand, [I-125][Leu(31),pro(34)]peptide YY, also binds with high affinity to the pancreatic polypeptide 1 receptor. Therefore, caution needs to be exercised when using Pro(34)-analogs to define the neuropeptide Y Y-1 receptor in vivo and using tissue preparations.
引用
收藏
页码:485 / 490
页数:6
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