Myosin V motor proteins: marching stepwise towards a mechanism

被引：104

作者：

Vale, RD

机构：

[1] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94107 USA

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94107 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 163卷 / 03期

关键词：

D O I：

10.1083/jcb.200308093

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.

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收藏

页码：445 / 450

页数：6

相关论文

共 27 条

[1] Myosin V is a left-handed spiral motor on the right-handed actin helix [J].

Ali, MY ;

Uemura, S ;

Adachi, K ;

Itoh, H ;

Kinosita, K ;

Ishiwata, S .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (06) :464-467

[2] The prepower stroke conformation of myosin V [J].

Burgess, S ;

Walker, M ;

Wang, F ;

Seller, JR ;

White, HD ;

Knight, PJ ;

Trinick, J .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :983-991

[3] A structural state of the myosin V motor without bound nucleotide [J].

Coureux, PD ;

Wells, AL ;

Ménétry, J ;

Yengo, CM ;

Morris, CA ;

Sweeney, HL ;

Houdusse, A .

NATURE, 2003, 425 (6956) :419-423

[4] The kinetic mechanism of myosin V [J].

De La Cruz, EM ;

Wells, AL ;

Rosenfeld, SS ;

Ostap, EM ;

Sweeney, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) :13726-13731

[5] Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization [J].

Forkey, JN ;

Quinlan, ME ;

Shaw, MA ;

Corrie, JET ;

Goldman, YE .

NATURE, 2003, 422 (6930) :399-404

[6] Electron cryo-microscopy shows how strong binding of myosin to actin releases nucleotide [J].

Holmes, KC ;

Angert, I ;

Kull, FJ ;

Jahn, W ;

Schröder, RR .

NATURE, 2003, 425 (6956) :423-427

[7] Distinguishing inchworm and hand-over-hand processive kinesin movement by neck rotation measurements [J].

Hua, W ;

Chung, J ;

Gelles, J .

SCIENCE, 2002, 295 (5556) :844-848

[8] Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin [J].

Ishijima, A ;

Kojima, H ;

Funatsu, T ;

Tokunaga, M ;

Higuchi, H ;

Tanaka, H ;

Yanagida, T .

CELL, 1998, 92 (02) :161-171

[9] Identification of an organelle-specific myosin V receptor [J].

Ishikawa, K ;

Catlett, NL ;

Novak, JL ;

Tang, F ;

Nau, JJ ;

Weisman, LS .

JOURNAL OF CELL BIOLOGY, 2003, 160 (06) :887-897

[10] A kinetic mechanism for the fast movement of Chara myosin [J].

Kimura, Y ;

Toyoshima, N ;

Hirakawa, N ;

Okamoto, K ;

Ishijima, A .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 328 (04) :939-950