SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis -: I.: Taxonomy, fermentation, isolation and biological activities

被引：59

作者：

Kurosawa, K ^{[1
]}

Takahashi, K ^{[1
]}

Tsuda, E ^{[1
]}

机构：

[1] Snow Brand Milk Prod Co Ltd, Life Sci Res Inst, Ishibashi, Tochigi 3290512, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 07期

关键词：

D O I：

10.7164/antibiotics.54.541

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

SNF4435C and D, novel nitrophenyl pyrones, have been isolated from the culture broth of an actinomycete strain SNF4435. The strain was identified as Streptomyces spectabilis from its morphological and cultural characteristics. SNF4435C and D showed a potent immuno-suppressive activity in vitro and selectively suppressed B-cell proliferation induced by LPS versus T-cell proliferation induced by Con A.

引用

页码：541 / 547

页数：7

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