Diversification of Escherichia coli expressing an SHV-type extended-spectrum β-lactamase (ESBL) during a hospital outbreak:: Emergence of an ESBL-hyperproducing strain resistant to expanded-spectrum cephalosporins

被引：20

作者：

Palucha, A

Mikiewicz, B

Gniadkowski, M

机构：

[1] Sera & Vaccines Cent Res Lab, PL-00725 Warsaw, Poland

[2] Hlth Care Ctr Praga Polnoc, PL-03719 Warsaw, Poland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.393

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Twelve SHV-type extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli lac mutant isolates were recovered in October 1997 from 11 patients of the neonatal ward in a Warsaw hospital. The outbreak was clonal; however, some of the isolates expressed a much higher level of resistance to several beta-lactam antibiotics, including expanded-spectrum cephalosporins. This phenotype has been attributed to beta-lactamase hyperproduction correlating with the multiplication of ESBL gene copies, as was demonstrated for representative isolates.

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页码：393 / 396

页数：4

相关论文

共 19 条

[1] A NEW PLASMIDIC CEFOTAXIMASE FROM PATIENTS INFECTED WITH SALMONELLA-TYPHIMURIUM [J].

BAUERNFEIND, A ;

CASELLAS, JM ;

GOLDBERG, M ;

HOLLEY, M ;

JUNGWIRTH, R ;

MANGOLD, P ;

ROHNISCH, T ;

SCHWEIGHART, S ;

WILHELM, R .

INFECTION, 1992, 20 (03) :158-163

[2] NUCLEOTIDE-SEQUENCE OF THE SHV-5 BETA-LACTAMASE GENE OF A KLEBSIELLA-PNEUMONIAE PLASMID [J].

BILLOTKLEIN, D ;

GUTMANN, L ;

COLLATZ, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (12) :2439-2441

[3] VARIATIONS BETWEEN THE NUCLEOTIDE-SEQUENCES OF TN1, TN2, AND TN3 AND EXPRESSION OF BETA-LACTAMASE IN PSEUDOMONAS-AERUGINOSA AND ESCHERICHIA-COLI [J].

CHEN, ST ;

CLOWES, RC .

JOURNAL OF BACTERIOLOGY, 1987, 169 (02) :913-916

[4] 2 IMPROVED PROMOTER SEQUENCES FOR THE BETA-LACTAMASE EXPRESSION ARISING FROM A SINGLE BASE-PAIR SUBSTITUTION [J].

CHEN, ST ;

CLOWES, RC .

NUCLEIC ACIDS RESEARCH, 1984, 12 (07) :3219-3234

[5] Hospital outbreak of Klebsiella pneumoniae resistant to broad-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations by hyperproduction of SHV-5 beta-lactamase [J].

French, GL ;

Shannon, KP ;

Simmons, N .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (02) :358-363

[6] Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals:: Identification of three novel TEM- and SHV-5-type extended-spectrum β-lactamases [J].

Gniadkowski, M ;

Schneider, I ;

Jungwirth, R ;

Hryniewicz, W ;

Bauernfeind, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (03) :514-520

[7] Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland:: Identification of a new CTX-M-3 cefotaxime-hydrolyzing β-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme [J].

Gniadkowski, M ;

Schneider, I ;

Palucha, A ;

Jungwirth, R ;

Mikiewicz, B ;

Bauernfeind, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (04) :827-832

[8] AN IS1-LIKE ELEMENT IS RESPONSIBLE FOR HIGH-LEVEL SYNTHESIS OF EXTENDED-SPECTRUM BETA-LACTAMASE TEM-6 IN ENTEROBACTERIACEAE [J].

GOUSSARD, S ;

SOUGAKOFF, W ;

MABILAT, C ;

BAUERNFEIND, A ;

COURVALIN, P .

JOURNAL OF GENERAL MICROBIOLOGY, 1991, 137 :2681-2687

[9]

HRYANIEWICZ W, 1996, 8 INT C BACT APPL MI

[10]

JARLIER V, 1988, REV INFECT DIS, V10, pS67