Induction of Hsp27 and Hsp32 stress proteins and vimentin in glial cells of the rat hippocampus following hyperthermia

被引：51

作者：

Bechtold, DA ^{[1
]}

Brown, IR ^{[1
]}

机构：

[1] Univ Toronto Scarborough, Div Life Sci, Ctr Neurobiol Stress, Toronto, ON M1C 1A4, Canada

来源：

NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 08期

关键词：

hyperthermia; Hsp27; Hsp32; heat shock protein; vimentin; astrocytes; microglia;

D O I：

10.1023/A:1024268126310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In response to stressful stimuli, cells respond by inducing a set of heat shock ( stress) proteins ( hsps) that play important roles in repair and protective mechanisms. The present study investigates the expression patterns of Hsp27 and Hsp32 in the adult rat hippocampus following whole body hyperthermia. A pronounced induction of these low-molecular-weight stress proteins was apparent in populations of glial cells such as astrocytes and microglia that were identified using cell-specific markers (GFAP for astrocytes and the lectin GSA I-B4 for microglia). Hyperthermia also resulted in a robust induction of the intermediate filament protein, vimentin, in glial cells in the adult rat hippocampus. Interestingly, a rapid induction of both Hsp27 and vimentin was observed in the microvasculature, suggesting that hyperthermic stress may compromise the blood-brain barrier.

引用

页码：1163 / 1173

页数：11

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