Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery

被引：123

作者：

Chen, Mark ^{[1
,2
]}

Zhang, Xue-Qing ^{[1
,2
]}

Man, Han B. ^{[1
,2
]}

Lam, Robert ^{[1
,2
]}

Chow, Edward K. ^{[3
]}

Ho, Dean ^{[1
,2
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[3] Univ Calif San Francisco, GW Hooper Fdn, San Francisco, CA USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2010年 / 1卷 / 21期

基金：

美国国家科学基金会;

关键词：

LOW-MOLECULAR-WEIGHT; NANOPARTICLES; RNA;

D O I：

10.1021/jz1013278

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The enormous therapeutic potential of RNA interference (RNAi) has long been recognized. While efficient small interfering RNA (SiRNA) delivery vectors exist, many sacrifice biocompatibility, which can challenge their applicability as a therapeutic agent. Nanodiamonds (NDs) represent promising strategies for efficient siRNA delivery given the multitude of beneficial properties integrated into one platform that include uniform particle sizes material scalability, the ability to carry nearly any type of therapeutic, and preserved biocompatibility, among others. Here we present a broadly applicable ND delivery platform that demonstrates biocompatible siRNA delivery with enhanced efficacy in media, signifying the translational potential of this approach.

引用

页码：3167 / 3171

页数：5

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