Stavudine or indinavir-containing regimens are associated with an increased risk of diabetes mellitus in HIV-infected individuals

被引：36

作者：

Brambilla, AM ^{[1
]}

Novati, R

Calori, G

Meneghini, E

Vacchini, D

Luzi, L

Castagna, A

Lazzarin, A

机构：

[1] Univ Vita Salute San Raffaele, Ist Sci San Raffaele, Infect Dis Clin, Milan, Italy

[2] Univ Vita Salute San Raffaele, Ist Sci San Raffaele, Clin Res Unit, Milan, Italy

[3] Univ Vita Salute San Raffaele, Ist Sci San Raffaele, Dept Internal Med, Milan, Italy

来源：

AIDS | 2003年 / 17卷 / 13期

关键词：

D O I：

10.1097/00002030-200309050-00022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diabetes mellitus was diagnosed in 16 out of 1011 HIV-positive patients over a median follow-up of 289 days (person-year incidence 2.06, 95% confidence interval 1.18-3.33). Significant risk factors for the onset of diabetes were older age and antiretroviral therapy with stavudine or indinavir. Older men with HIV infection should be considered at higher risk of diabetes, and caution may be warranted in the use of both indinavir and stavudine in these patients.

引用

页码：1993 / 1995

页数：3

共 12 条

[1]

Bogner JR, 2001, J ACQ IMMUN DEF SYND, V27, P237, DOI 10.1097/00126334-200107010-00004

[2] Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study [J].

Carr, A ;

Samaras, K ;

Thorisdottir, A ;

Kaufmann, GR ;

Chisholm, DJ ;

Cooper, DA .

LANCET, 1999, 353 (9170) :2093-2099

[3] A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors [J].

Carr, A ;

Samaras, K ;

Burton, S ;

Law, M ;

Freund, J ;

Chisholm, DJ ;

Cooper, DA .

AIDS, 1998, 12 (07) :F51-F58

[4]

CURRIER JS, 2002, 9 C RETR OPP INF WAS

[5] Age-specific incidence and duration of known diabetes - The Cremona study [J].

Garancini, MP ;

Gobbi, C ;

Errera, A ;

Sergi, A ;

Gallus, G .

DIABETES CARE, 1996, 19 (11) :1279-1282

[6]

Gavin JR, 1997, DIABETES CARE, V20, P1183

[7] Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy [J].

Hadigan, C ;

Meigs, JB ;

Corcoran, C ;

Rietschel, P ;

Piecuch, S ;

Basgoz, N ;

Davis, B ;

Sax, P ;

Stanley, T ;

Wilson, PWF ;

D'Agostino, RB ;

Grinspoon, S .

CLINICAL INFECTIOUS DISEASES, 2001, 32 (01) :130-139

[8] Drug-induced hyperglycemia [J].

Luna, B ;

Feinglos, MN .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (16) :1945-1948

[9] Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection [J].

Mallal, SA ;

John, M ;

Moore, CB ;

James, IR ;

McKinnon, EJ .

AIDS, 2000, 14 (10) :1309-1316

[10] The mechanism of insulin resistance caused by HIV protease inhibitor therapy [J].

Murata, H ;

Hruz, PW ;

Mueckler, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20251-20254

← 1 2 →