Sarcolemmal sodium-calcium exchanger

被引：49

作者：

Ford, DA ^{[1
]}

Hale, CC ^{[1
]}

机构：

[1] UNIV MISSOURI,DALTON CARDIOVASC RES CTR,DEPT VET BIOMED SCI,COLUMBIA,MO

来源：

FEBS LETTERS | 1996年 / 394卷 / 01期

关键词：

plasmalogen; sodium-calcium exchange; sarcolemma; phospholipid; myocardium;

D O I：

10.1016/0014-5793(96)00930-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although plasmalogens are the predominant phospholipids of cardiac sarcolemma, their physiological role has not been forthcoming, Since the cardiac sarcolemmal sodium-calcium exchanger has been proposed to be regulated by anionic phospholipids, the roles of plasmalogens and anionic phospholipids as regulators of the sodium-calcium exchanger were explored, Reconstituted sodium-calcium exchange activity in plasmalogen-containing proteoliposomes was Id-fold higher than that in control proteoliposomes comprised of only diacyl phospholipids. Additionally, exchange activity in plasmalogen-containing proteoliposomes was regulated by anionic phospholipids, Thus, plasmalogens provide a critical lipid environment in which anionic phospholipids serve as boundary lipids for the regulation of the trans-sarcolemmal sodium-calcium exchanger.

引用

页码：99 / 102

页数：4

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