Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection

被引：49

作者：

Shim, TS ^{[1
]}

Turner, OC ^{[1
]}

Orme, IM ^{[1
]}

机构：

[1] Colorado State Univ, Mycobacteria Res Labs, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

TUBERCULOSIS | 2003年 / 83卷 / 06期

关键词：

toll-like receptors; C3H mice; aerosol infection;

D O I：

10.1016/S1472-9792(03)00071-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although various members of the pattern recognition Toll-like receptor (TLR) family have been implicated in host resistance to Mycobacterium tuberculosis infection, it remains unclear if the TLR4 receptor plays an important role. We demonstrate here that infection of TRL4-competent and TLR4-deficient mice on the C3 H inbred mouse strain background had similar outcomes, measured in terms of the course of the disease, cell accumulation patterns in the lungs, and lung histopathology. These data argue against a significant role for TLR4 in immunity to tuberculosis in the mouse model. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：367 / 371

页数：5

共 19 条

[1] Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice [J].