Involvement of leukotriene B4 in arthritis models

被引：25

作者：

Tsuji, F ^{[1
]}

Oki, K ^{[1
]}

Fujisawa, K ^{[1
]}

Okahara, A ^{[1
]}

Horiuchi, M ^{[1
]}

Mita, S ^{[1
]}

机构：

[1] Santen Pharmaceut Co Ltd, Div Discovery Res, Higashiyodogawa Ku, Osaka 5338651, Japan

来源：

LIFE SCIENCES | 1998年 / 64卷 / 03期

关键词：

leukotriene B-4; leukotriene A(4); hydrolase inhibitor; SA6541; collagen-induced arthritis; MDP-induced arthritis; synovial stromal cell;

D O I：

10.1016/S0024-3205(98)00556-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

We investigated the role of leukotriene B4 (LTB4) in murine arthritis models using a leukotriene A4 (LTA4) hydrolase inhibitor, SA6541. SA6541 inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo. SA6541 also inhibited LTA4-induced hyperproliferation of synovial stromal cells in vitro. These results suggest that LTB4 may play an important role in arthritis models. (C) 1998 Elsevier Science Inc.

引用

页码：PL51 / PL56

页数：6

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