Neurotoxicity of Generic Anesthesia Agents in Infants and Children An Orphan Research Question in Search of a Sponsor

被引：41

作者：

Psaty, Bruce M. ^{[1
,2
,3
]}

Platt, Richard ^{[4
,5
]}

Altman, Russ B. ^{[6
,7
]}

机构：

[1] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[2] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[3] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA

[6] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[7] Stanford Univ, Dept Genet & Med, Stanford, CA 94305 USA

来源：

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2015年 / 313卷 / 15期

关键词：

NEURODEGENERATION; EXPOSURE;

D O I：

10.1001/jama.2015.1149

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1515 / 1516

页数：2

共 10 条

[1]

Andropoulos DB, FDA PUBLIC SESSION R

[2] Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain [J].

Brambrink, Ansgar M. ;

Back, Stephen A. ;

Riddle, Art ;

Gong, Xi ;

Moravec, Matthew D. ;

Dissen, Gregory A. ;

Creeley, Catherine E. ;

Dikranian, Krikor T. ;

Olney, John W. .

ANNALS OF NEUROLOGY, 2012, 72 (04) :525-535

[3] Newly Postulated Neurodevelopmental Risks of Pediatric Anesthesia: Theories That Could Rock Our World [J].

Hays, Stephen Robert ;

Deshpande, Jayant K. .

JOURNAL OF UROLOGY, 2013, 189 (04) :1222-1228

[4] Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain [J].

Ikonomidou, C ;

Bosch, F ;

Miksa, M ;

Bittigau, P ;

Vöckler, J ;

Dikranian, K ;

Tenkova, TI ;

Stefovska, V ;

Turski, L ;

Olney, JW .

SCIENCE, 1999, 283 (5398) :70-74

[5] Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia [J].

Ing, Caleb ;

DiMaggio, Charles ;

Whitehouse, Andrew ;

Hegarty, Mary K. ;

Brady, Joanne ;

von Ungern-Sternberg, Britta S. ;

Davidson, Andrew ;

Wood, Alastair J. J. ;

Li, Guohua ;

Sun, Lena S. .

PEDIATRICS, 2012, 130 (03) :E476-E485

[6] Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits [J].

Jevtovic-Todorovic, V ;

Hartman, RE ;

Izumi, Y ;

Benshoff, ND ;

Dikranian, K ;

Zorumski, CF ;

Olney, JW ;

Wozniak, DF .

JOURNAL OF NEUROSCIENCE, 2003, 23 (03) :876-882

[7] Genomic responses in mouse models poorly mimic human inflammatory diseases [J].

Seok, Junhee ;

Warren, H. Shaw ;

Cuenca, Alex G. ;

Mindrinos, Michael N. ;

Baker, Henry V. ;

Xu, Weihong ;

Richards, Daniel R. ;

McDonald-Smith, Grace P. ;

Gao, Hong ;

Hennessy, Laura ;

Finnerty, Celeste C. ;

Lopez, Cecilia M. ;

Honari, Shari ;

Moore, Ernest E. ;

Minei, Joseph P. ;

Cuschieri, Joseph ;

Bankey, Paul E. ;

Johnson, Jeffrey L. ;

Sperry, Jason ;

Nathens, Avery B. ;

Billiar, Timothy R. ;

West, Michael A. ;

Jeschke, Marc G. ;

Klein, Matthew B. ;

Gamelli, Richard L. ;

Gibran, Nicole S. ;

Brownstein, Bernard H. ;

Miller-Graziano, Carol ;

Calvano, Steve E. ;

Mason, Philip H. ;

Cobb, J. Perren ;

Rahme, Laurence G. ;

Lowry, Stephen F. ;

Maier, Ronald V. ;

Moldawer, Lyle L. ;

Herndon, David N. ;

Davis, Ronald W. ;

Xiao, Wenzhong ;

Tompkins, Ronald G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) :3507-3512

[8]

US Food and Drug Administration, SIGN EX NONCL CLIN D

[9]

US Food and Drug Administration, CLIN INV POT EFF AN

[10]

Yu CK, 2013, F1000RESEARCH, V2, P166, DOI [10.12688/f1000research.2-166.v1, DOI 10.12688/F1000RESEARCH.2-166.V1]

← 1 →