Enzyme redesign

被引：106

作者：

Penning, TM

Jez, JM

机构：

[1] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

[2] Salk Inst Biol Studies, Struct Biol Lab, La Jolla, CA 92037 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 10期

关键词：

D O I：

10.1021/cr000049n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The various techniques used for enzyme redesigning were discussed. The process enzyme redesign addresses questions of catalysis and ligand recognition and provides a basis for the applied use of engineered enzymes. The results show that modification of stereochemical outcome of a reaction has practical benefits as many enzymes serve as chiral catalysts for synthetic purposes in the chemical and pharmaceutical industry.

引用

收藏

页码：3027 / 3046

页数：20

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