Molecular biology of alcohol dependence, a complex polygenic disorder

被引：5

作者：

Whitfield, JB ^{[1
]}

Nightingale, BN

O'Brien, ME

Heath, AC

Birley, AJ

Martin, NG

机构：

[1] Royal Prince Alfred Hosp, Dept Clin Biochem, Camperdown, NSW 2050, Australia

[2] Washington Univ, Dept Psychiat, St Louis, MO USA

[3] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 1998年 / 36卷 / 08期

关键词：

D O I：

10.1515/CCLM.1998.111

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Alcohol dependence, and the medical conditions which arise from prolonged excessive alcohol use, have no single cause. Like other complex diseases, they result from a combination of social, personal and genetic contributions; but within any society genetic variation has a substantial influence on individual risk. The genes presently known to affect alcohol dependence produce variation in alcohol metabolism; other genes which affect personality or susceptibility to intoxication are likely to be significant but so far reproducible evidence is scanty. Designs which include related subjects have advantages for the study of complex diseases, because any association effects can be placed in the context of overall heritability and because linkage analysis can also be included. Examples of our studies of alcohol metabolism, consumption and dependence are presented.

引用

页码：633 / 636

页数：4

共 13 条

[1] Short-term selective breeding as a tool for QTL mapping: Ethanol preference drinking in mice [J].

Belknap, JK ;

Richards, SP ;

OToole, LA ;

Helms, ML .

BEHAVIOR GENETICS, 1997, 27 (01) :55-66

[2]

CLONINGER CR, 1981, ARCH GEN PSYCHIAT, V38, P861

[3] THE A1 ALLELE AT THE D2-DOPAMINE RECEPTOR GENE AND ALCOHOLISM - A REAPPRAISAL [J].

GELERNTER, J ;

GOLDMAN, D ;

RISCH, N .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (13) :1673-1677

[4]

GOODWIN DW, 1973, ARCH GEN PSYCHIAT, V28, P238

[5] POSSIBLE PROTECTIVE ROLE AGAINST ALCOHOLISM FOR ALDEHYDE DEHYDROGENASE ISOENZYME DEFICIENCY IN JAPAN [J].

HARADA, S ;

AGARWAL, DP ;

GOEDDE, HW ;

TAGAKI, S ;

ISHIKAWA, B .

LANCET, 1982, 2 (8302) :827-827

[6] Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men [J].

Heath, AC ;

Bucholz, KK ;

Madden, PAF ;

Dinwiddie, SH ;

Slutske, WS ;

Bierut, LJ ;

Statham, DJ ;

Dunne, MP ;

Whitfield, JB ;

Martin, NG .

PSYCHOLOGICAL MEDICINE, 1997, 27 (06) :1381-1396

[7]

HIGUCHI S, 1996, BIOL ALCOHOL PROBLEM

[8] GENETIC AND ENVIRONMENTAL-INFLUENCES ON LIFETIME ALCOHOL-RELATED PROBLEMS IN A VOLUNTEER SAMPLE OF OLDER TWINS [J].

PRESCOTT, CA ;

HEWITT, JK ;

TRUETT, KR ;

HEATH, AC ;

NEALE, MC ;

EAVES, LJ .

JOURNAL OF STUDIES ON ALCOHOL, 1994, 55 (02) :184-202

[9]

Reich T, 1998, AM J MED GENET, V81, P207, DOI 10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO

[10]

2-T

← 1 2 →