Molecular biology - Getting p53 out of the nucleus

被引：47

作者：

Gottifredi, V ^{[1
]}

Prives, C ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

SCIENCE | 2001年 / 292卷 / 5523期

关键词：

D O I：

10.1126/science.1062238

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

引用

收藏

页码：1851 / 1852

页数：2

相关论文

共 16 条

[1]

Regulation of p53 stability [J].

Ashcroft, M ;

Vousden, KH .

ONCOGENE, 1999, 18 (53) :7637-7643

[2]

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 [J].

Boyd, SD ;

Tsai, KY ;

Jacks, T .

NATURE CELL BIOLOGY, 2000, 2 (09) :563-568

[3]

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2 [J].

Dumaz, N ;

Meek, DW .

EMBO JOURNAL, 1999, 18 (24) :7002-7010

[4]

JNK targets p53 ubiquitination and degradation in nonstressed cells [J].

Fuchs, SY ;

Adler, V ;

Buschmann, T ;

Yin, ZM ;

Wu, XW ;

Jones, SN ;

Ronai, Z .

GENES & DEVELOPMENT, 1998, 12 (17) :2658-2663

[5]

The MDM2 RING-finger domain is required to promote p53 nuclear export [J].

Geyer, RK ;

Yu, ZK ;

Maki, CG .

NATURE CELL BIOLOGY, 2000, 2 (09) :569-573

[6]

The complexity of p53 modulation: emerging patterns from divergent signals [J].

Giaccia, AJ ;

Kastan, MB .

GENES & DEVELOPMENT, 1998, 12 (19) :2973-2983

[7]

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation [J].

Kapoor, M ;

Hamm, R ;

Yan, W ;

Taya, Y ;

Lozano, G .

ONCOGENE, 2000, 19 (03) :358-364

[8]

Accumulating active p53 in the nucleus by inhibition of nuclear export:: A novel strategy to promote the p53 tumor suppressor function [J].

Laín, S ;

Xirodimas, D ;

Lane, DP .

EXPERIMENTAL CELL RESEARCH, 1999, 253 (02) :315-324

[9]

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage [J].

Maya, R ;

Balass, M ;

Kim, ST ;

Shkedy, D ;

Leal, JFM ;

Shifman, O ;

Moas, M ;

Buschmann, T ;

Ronai, Z ;

Shiloh, Y ;

Kastan, MB ;

Katzir, E ;

Oren, M .

GENES & DEVELOPMENT, 2001, 15 (09) :1067-1077

[10]

Prives C, 1999, J PATHOL, V187, P112