Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium

被引：42

作者：

Gill, KA ^{[1
]}

Brindle, NPJ ^{[1
]}

机构：

[1] Univ Leicester, Dept Cardiovasc Sci, RKCSB, Leicester LE2 7LX, Leics, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 336卷 / 02期

关键词：

endothelial progenitor; migration; angiopoietins;

D O I：

10.1016/j.bbrc.2005.08.097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The factors controlling recruitment of endogenous and transplanted endothelial progenitor cells (EPC) to areas of neovascularization are largely unknown. In this study, we have examined the possibility that EPC migration and adhesion could be regulated by angiopoietin-2 (Ang2), a soluble ligand expressed by endothelial cells at sites of vessel remodelling and angiogenesis. We show for the first time that Ang2 causes a marked stimulation of EPC migration. This was specific for EPC as the ligand failed to affect endothelial cell migration. Ang2-stimulated EPC migration was inhibited by soluble Tie2 ectodomain. Furthermore, the ligand stimulated adhesion between EPC and endothelial monolayers. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：392 / 396

页数：5

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