Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

被引：1326

作者：

Li, Jia-Yi ^{[1
]}

Englund, Elisabet ^{[2
]}

Holton, Janice L. ^{[3
]}

Soulet, Denis ^{[1
]}

Hagell, Peter ^{[4
]}

Lees, Andrew J. ^{[3
]}

Lashley, Tammaryn ^{[3
]}

Quinn, Niall P. ^{[5
]}

Rehncrona, Stig ^{[6
]}

Bjorklund, Anders ^{[7
]}

Widner, Hakan ^{[4
]}

Revesz, Tamas ^{[3
]}

Lindvall, Olle ^{[4
,8
]}

Brundin, Patrik ^{[1
]}

机构：

[1] Wallenberg Neurosci Ctr, Neuronal Survival Unit, Dept Expt Med Sci, S-22184 Lund, Sweden

[2] Univ Lund Hosp, Div Neuropathol, S-22185 Lund, Sweden

[3] UCL, Inst Neurol, Queen Square Brain Bank Neurol Disorders, Dept Mol Neurosci, London WC1N 3BG, England

[4] Univ Lund Hosp, Div Neurol, S-22185 Lund, Sweden

[5] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England

[6] Univ Lund Hosp, Div Neurosurg, S-22185 Lund, Sweden

[7] Wallenberg Neurosci Ctr, Neurobiol Unit, S-22184 Lund, Sweden

[8] Wallenberg Neurosci Ctr, Sect Restorat Neurol, S-22184 Lund, Sweden

来源：

NATURE MEDICINE | 2008年 / 14卷 / 05期

关键词：

D O I：

10.1038/nm1746

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.

引用

页码：501 / 503

页数：3

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