The role of cGAS in innate immunity and beyond

被引：54

作者：

Ablasser, Andrea ^{[1
]}

Gulen, Muhammed F. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2016年 / 94卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

Innate immunity; DNA sensing; Type I interferons; CYCLIC GMP-AMP; DNA SENSOR CGAS; AICARDI-GOUTIERES SYNDROME; MITOCHONDRIAL-DNA; SENSING PATHWAY; I INTERFERONS; SYNTHASE; ACTIVATION; 2ND-MESSENGER; INDUCTION;

D O I：

10.1007/s00109-016-1423-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases and controls immune responses that underlie cancer immunosurveillance. In this review, we highlight our current understanding of DNA sensing by cGAS and its involvement in human disease.

引用

页码：1085 / 1093

页数：9

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