Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea

被引:69
作者
Xiao, SD
Zhang, DZ
Lu, H
Jiang, SH
Liu, HY
Wang, GS
Xu, GM
Zhang, ZB
Lin, GJ
Wang, GL
机构
[1] Shanghai Med Univ, Shanghai Renji Hosp, Shanghai Inst Digest Dis, Shanghai 200001, Peoples R China
[2] Shanghai Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China
[3] Shanghai Huadong Hosp, Shanghai, Peoples R China
[4] Chineses Second Mil Med Univ, Changhai Hosp, Shanghai, Peoples R China
[5] Chineses Second Mil Med Univ, Changzheng Hosp, Shanghai, Peoples R China
[6] Shanghai Fudan Univ, Huashan Hosp, Shanghai, Peoples R China
[7] Shanghai First Peoples Hosp, Shanghai, Peoples R China
关键词
chronic diarrhea; lactobacilli; Lactobacillus acidophilus LB; probiotics;
D O I
10.1007/BF02849854
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Chronic diarrhea is a common bowel disorder; disturbance of intestinal microorganisms may play a role in its pathogenesis. This study assessed the clinical efficacy of lyophilized, heat-killed Lactobacillus acidophilus LB versus living lactobacilli in the treatment of chronic diarrhea. One hundred thirty-seven patients with chronic diarrhea were randomly allocated to receive either a 4-week course of 2 capsules of Lacteol(R) Fort twice a day (Lacteol group, 69 patients) or a 4-week course of 5 chewable tablets of Lacidophilin(R) three times a day (Lacidophilin group, 64 patients). The frequency of stools was recorded quantitatively, and semi-quantitative parameters such as stool consistency, abdominal pain, distention, and feeling of incomplete evacuation were evaluated. At the second and fourth week of treatment, mean bowel frequency was significantly lower in the Lacteol group than in the Lacidophilin group (1.88+/-1.24 vs 2.64+/-1.12, 1.39+/-0.92 vs 2.19+/-1.05; P<.05). At the end of the treatment, the clinical symptoms were markedly improved in the Lacteol group, indicating that L. acidophilus LB is more effective than living lactobacilli in the treatment of chronic diarrhea.
引用
收藏
页码:253 / 260
页数:8
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