A new synthesis of the labeling precursor for [18F]-fluoromisonidazole

被引：19

作者：

Adamsen, TCH ^{[1
]}

Grierson, JR ^{[1
]}

Krohn, KA ^{[1
]}

机构：

[1] Univ Washington, Dept Radiol, Mol Imaging Res Ctr, Seattle, WA 98195 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2005年 / 48卷 / 12期

关键词：

hypoxia; misonidazole; fluorine-18; positron emission tomography;

D O I：

10.1002/jlcr.1001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[F-18]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [F-18]-fluoromisonidazole was prepared from 1,3-dibromo-2-propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：923 / 927

页数：5