Benign prostatic hyperplasia (BPH) is a common age related proliferative abnormality of the human prostate. Histological features demonstrate that the typical nodules of BPH are composed of stromal and epithelial. cells that are proportionally different between nodules. BPH nodules frequently occur concurrently with chronic inflammatory infiltrates, mainly composed of chronically activated T cells and macrophages. Recent studies suggest that these inflammatory cells, immunity responses and their precursors play important roles in the pathogenesis of BPH. Clinical evidences also indicate that chronic inflammation correlates with clinical progression of BPH. Therefore, we hypothesize that BPH is an inflammatory disease. Reducing inflammation may play a crucial role in the treatment of BPH and finally lead to a better clinical outcome. If our hypotheses can be further supported with clinical trials it may change the approach of the medical management for BPH. (C) 2007 Elsevier Ltd. All rights reserved.
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Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Gerstenbluth, RE
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Seftel, AD
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Seftel, AD
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MacLennan, GT
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
MacLennan, GT
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Rao, RN
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Rao, RN
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Corty, EW
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Corty, EW
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Ferguson, K
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Ferguson, K
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Resnick, MI
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
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Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USACase Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Gerstenbluth, RE
;
Seftel, AD
论文数: 0引用数: 0
h-index: 0
机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Seftel, AD
;
MacLennan, GT
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h-index: 0
机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
MacLennan, GT
;
Rao, RN
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Rao, RN
;
Corty, EW
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Corty, EW
;
Ferguson, K
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
Ferguson, K
;
Resnick, MI
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机构:Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA