The link between IL-23 and Th17 cell-mediated immune pathologies

被引：125

作者：

McGeachy, Mandy J. ^{[1
]}

Cua, Daniel J. ^{[1
]}

机构：

[1] Schering Plough Biopharma, Palo Alto, CA 94304 USA

来源：

SEMINARS IN IMMUNOLOGY | 2007年 / 19卷 / 06期

关键词：

autoimmunity; inflammation; T cell lineage commitment; IL-17; TGF-beta; IL-6; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA; T-HELPER-CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; DENDRITIC CELLS; EFFECTOR PHASE; CUTTING EDGE; TGF-BETA; CHRONIC INFLAMMATION;

D O I：

10.1016/j.smim.2007.10.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-23-produced by dendritic cells-and Th17 cells have both been identified as major factors involved in autoimmune inflammation, yet their relationship with each other remains controversial. This review aims to describe the initial discovery of Th17 cells, their subsequent characterization as a unique T helper subset in mouse and man, as well as the mechanisms involved in regulating these cells. Finally, the roles of IL-23 in inflammatory diseases in relation to Th17 function will be discussed. (C) 2007 Published by Elsevier Ltd.

引用

页码：372 / 376

页数：5

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