Tampering with Prescription Opioids: Nature and Extent of the Problem, Health Consequences, and Solutions

被引：120

作者：

Katz, Nathaniel ^{[1
,2
]}

Dart, Richard C. ^{[3
]}

Bailey, Elise ^{[3
]}

Trudeau, Jeremiah ^{[1
]}

Osgood, Eric ^{[1
]}

Paillard, Florence ^{[4
]}

机构：

[1] Analges Solut, Natick, MA 01760 USA

[2] Tufts Univ, Sch Med, Boston, MA 02111 USA

[3] Denver Hlth, Rocky Mt Poison & Drug Ctr, Denver, CO USA

[4] FocusBiocom, Durango, CO USA

来源：

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE | 2011年 / 37卷 / 04期

关键词：

analgesics; opioid; tampering; opioid abuse; prescription opioid; public health; ABUSE-DETERRENT; DRUG-USERS; BUPRENORPHINE; SYSTEM; PHARMACOKINETICS; GRANULOMATOSIS; FORMULATIONS; INJECTION; DIVERSION;

D O I：

10.3109/00952990.2011.569623

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: Transdermal and solid oral prescription opioid (PO) formulations can be abused by ingesting (with or without tampering), snorting, or injection (both requiring tampering). Objective: To determine the patterns of tampering with POs for abuse. Methods: Information was collected from published studies and databases. Results: Tampering with POs for abuse is common practice. Ingestion is the most prevalent method of abuse, followed by snorting and injection. From 1992 to 2002, injecting POs has decreased in favor of ingesting and snorting. Methods of abuse vary widely by product. Abuse methods with the highest morbidity are injection and inhalation. Conclusions: The seriousness of health outcomes associated with tampering with POs warrants the development of PO formulations that prevent or deter tampering.

引用

页码：205 / 217

页数：13

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