A decade of exploring the cancer epigenome - biological and translational implications

被引：2069

作者：

Baylin, Stephen B. ^{[1
]}

Jones, Peter A. ^{[2
]}

机构：

[1] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

[2] Univ So Calif, USC Norris Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; HISTONE DEACETYLASE INHIBITION; METHYLTRANSFERASE GENE EZH2; DNA METHYLATION PATTERNS; TUMOR-SUPPRESSOR GENES; CPG-ISLAND METHYLATION; EMBRYONIC STEM-CELLS; COLORECTAL-CANCER; PROSTATE-CANCER; MYELODYSPLASTIC SYNDROMES;

D O I：

10.1038/nrc3130

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The past decade has highlighted the central role of epigenetic processes in cancer causation, progression and treatment. Next-generation sequencing is providing a window for visualizing the human epigenome and how it is altered in cancer. This view provides many surprises, including linking epigenetic abnormalities to mutations in genes that control DNA methylation, the packaging and the function of DNA in chromatin, and metabolism. Epigenetic alterations are leading candidates for the development of specific markers for cancer detection, diagnosis and prognosis. The enzymatic processes that control the epigenome present new opportunities for deriving therapeutic strategies designed to reverse transcriptional abnormalities that are inherent to the cancer epigenome.

引用

页码：726 / 734

页数：9

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