Comparative evaluation of D-glucosyl thiouronium, glucosylthio heterocycles, Daonil, and insulin as inhibitors for hepatic glycosidases

被引：27

作者：

Awad, OMED

Attia, WE

El Ashry, ESH ^{[1
]}

机构：

[1] Univ Alexandria, Fac Sci, Dept Biochem, Alexandria 21321, Egypt

[2] Univ Alexandria, Fac Sci, Dept Chem, Alexandria 21321, Egypt

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 03期

关键词：

alpha-glucosidase; beta-glucosidase; glucopyranosylthio; thiouronium; thiadiazolinthione; benzoxazole;

D O I：

10.1016/j.carres.2003.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Comparison of the in vivo and in vitro effects of S-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)thiuronium bromide (1), 2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylthio-1,3,4-thiadiazolin-5-thione (2), and 2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylthio)-1,3-benzoxazole (3), as well as the antidiabetics Daonil and insulin on glycosidase enzymes has been investigated. Compound 1 inhibited both alpha- and beta-glucosidases, but the inhibition was more potent with the beta-enzyme. Compound 2 was found to be a weaker inhibitor of these enzymes, while compound 3 showed a slight apparent activation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：469 / 476

页数：8

共 48 条

[1]

Synthesis of C-(D-glycopyranosyl)ethylamines and C-(D-glycofuranosyl)methylamines as potential glycosidase inhibitors [J].