Four deaths and a funeral:: From caspases to alternative mechanisms

被引：1300

作者：

Leist, M

Jäättelä, M

机构：

[1] H Lundbeck & Co AS, DK-2500 Copenhagen, Denmark

[2] Danish Canc Soc, Apoptosis Lab, DK-2100 Copenhagen, Denmark

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/35085008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.

引用

收藏

页码：589 / 598

页数：10

相关论文

共 115 条

[1] Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene [J].

Alexander, CM ;

Howard, EW ;

Bissell, MJ ;

Werb, Z .

JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1669-1677

[2] Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death [J].

Amarante-Mendes, GP ;

Finucane, DM ;

Martin, SJ ;

Cotter, TG ;

Salvesen, GS ;

Green, DR .

CELL DEATH AND DIFFERENTIATION, 1998, 5 (04) :298-306

[3] The origin of programmed cell death [J].

Ameisen, JC .

SCIENCE, 1996, 272 (5266) :1278-1279

[4] Apoptotic molecular machinery: Vastly increased complexity in vertebrates revealed by genome comparisons [J].

Aravind, L ;

Dixit, VM ;

Koonin, EV .

SCIENCE, 2001, 291 (5507) :1279-+

[5] Horizontal transfer of oncogenes by uptake of apoptotic bodies [J].

Bergsmedh, A ;

Szeles, A ;

Henriksson, M ;

Bratt, A ;

Folkman, MJ ;

Spetz, AL ;

Holmgren, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6407-6411

[6] CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4+ T cells [J].

Berndt, C ;

Möpps, B ;

Angermüller, S ;

Gierschik, P ;

Krammer, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12556-12561

[7] Salmonella-induced cell death:: apoptosis, necrosis or programmed cell death? [J].

Boise, LH ;

Collins, CM .

TRENDS IN MICROBIOLOGY, 2001, 9 (02) :64-67

[8] Apoptosis without caspases: an inefficient molecular guillotine? [J].

Borner, C ;

Monney, L .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (06) :497-507

[9] Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy [J].

Bursch, W ;

Ellinger, A ;

Kienzl, H ;

Torok, L ;

Pandey, S ;

Sikorska, M ;

Walker, R ;

Hermann, RS .

CARCINOGENESIS, 1996, 17 (08) :1595-1607

[10] Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx [J].

Chang, HY ;

Nishitoh, H ;

Yang, XL ;

Ichijo, H ;

Baltimore, D .

SCIENCE, 1998, 281 (5384) :1860-1863

← 1 2 3 4 5 6 7 8 9 10 →