Mass spectrometry in the combinatorial chemistry revolution

被引：43

作者：

Loo, JA

机构：

来源：

EUROPEAN MASS SPECTROMETRY | 1997年 / 3卷 / 02期

关键词：

electrospray ionization (ESI); matrix-assisted laser desorption ionization (MALDI); secondary ion mass spectrometry (SIMS); noncovalent complexes; beads; affinity selection; combinatorial library; mixture analysis; capillary electrophoresis; tandem mass spectrometry (MS/MS);

D O I：

10.1255/ejms.7

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The integration of mass spectrometry and combinatorial chemistry is becoming commonplace in many laboratory settings, Combinatorial chemistry provides a means for synthesis of mixtures of large numbers of compounds, thereby greatly increasing the diversity of molecular architectures available for screening, Mass spectrometry is being utilized as a rapid and sensitive tool not only to characterize combinatorial libraries, but also to aid in the identification of active compounds.

引用

页码：93 / 104

页数：12

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