Recognition of Sialylated Poly-N-acetyllactosamine Chains on N- and O-Linked Glycans by Human and Avian Influenza A Virus Hemagglutinins

被引：68

作者：

Nycholat, Corwin M. ^{[1
]}

McBride, Ryan ^{[1
]}

Ekiert, Damian C. ^{[2
]}

Xu, Rui ^{[2
]}

Rangarajan, Janani ^{[1
]}

Peng, Wenjie ^{[1
]}

Razi, Nahid ^{[1
]}

Gilbert, Michel ^{[3
]}

Wakarchuk, Warren ^{[3
]}

Wilson, Ian A. ^{[2
]}

Paulson, James C. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 20期

关键词：

glycans; hemagglutinins; influenza viruses; microarrays; sialic acids; RECEPTOR SPECIFICITY; CHEMOENZYMATIC SYNTHESIS; MICROARRAY; TRANSMISSION; BINDING;

D O I：

10.1002/anie.201200596

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4860 / 4863

页数：4

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