A quantitative neuromotor predictor of antidepressant non-response in patients with major depression

被引:43
作者
Caligiuri, MP
Gentili, V
Eberson, S
Kelsoe, J
Rapaport, M
Gillin, JC
机构
[1] Univ Calif San Diego, Psychiat Serv 0603, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, VA San Diego Healthcare Syst, Psychiat Serv, La Jolla, CA 92093 USA
关键词
psychomotor retardation; clinical trials; parkinsonism; antidepressant response;
D O I
10.1016/S0165-0327(02)00107-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Predicting response to antidepressant medication has been a challenge to clinicians and researchers for decades. Attention has been paid to the role of motor retardation as a putative indicator of treatment response, yet previous findings have been mixed. One reason for this inconsistency may be related to the subjective nature of motor retardation and how it is assessed. In the present study, we adopted a measure of motor programming previously shown to characterize parkinsonian bradykinesia to test whether neuromotor function could predict response to antidepressant treatment. Twenty-eight patients (14 males and 14 females with a mean age of 42.0 years) meeting DSM-IV criteria for a depressive disorder were randomized to receive 8 weeks of treatment with one of three antidepressant medications (sertraline, phenelzine, or bupropion). Treatment outcomes were assessed using the 17-item version of the Hamilton Rating Scale for Depression (HRSD). Patients were considered asymptomatic if their post-treatment HRSD total score was equal to or less than 7. Treatment responders (n = 15) had significantly less baseline impairment (P=0.01) on the neuromotor measure than non-responders (n = 13). There was a significant relationship between amount of improvement on the HRSD and severity of baseline neuromotor function (r=-0.51; P=0.006). No significant group effects were found for baseline psychomotor slowing or clinical ratings of motor retardation. These results demonstrate that a quantitative measure of motor programming may be a useful predictor of antidepressant non-response. (C) 2002 Published by Elsevier B.V.
引用
收藏
页码:135 / 141
页数:7
相关论文
共 16 条
[1]  
Berman R M, 1997, Depress Anxiety, V5, P154, DOI 10.1002/(SICI)1520-6394(1997)5:4<154::AID-DA2>3.0.CO
[2]  
2-D
[3]  
Bruder G E, 1999, CNS Spectr, V4, P30
[4]   Motor and cognitive aspects of motor retardation in depression [J].
Caligiuri, MP ;
Ellwanger, J .
JOURNAL OF AFFECTIVE DISORDERS, 2000, 57 (1-3) :83-93
[5]   Scaling of movement velocity: A measure of neuromotor retardation in individuals with psychopathology [J].
Caligiuri, MP ;
Lohr, JB ;
Ruck, RK .
PSYCHOPHYSIOLOGY, 1998, 35 (04) :431-437
[6]  
Dantchev N, 1998, J CLIN PSYCHIAT, V59, P19
[7]  
Flament MF, 1999, INT CLIN PSYCHOPHARM, V14, P259
[8]   CONCEPTUALIZATION AND RATIONALE FOR CONSENSUS DEFINITIONS OF TERMS IN MAJOR DEPRESSIVE DISORDER - REMISSION, RECOVERY, RELAPSE, AND RECURRENCE [J].
FRANK, E ;
PRIEN, RF ;
JARRETT, RB ;
KELLER, MB ;
KUPFER, DJ ;
LAVORI, PW ;
RUSH, AJ ;
WEISSMAN, MM .
ARCHIVES OF GENERAL PSYCHIATRY, 1991, 48 (09) :851-855
[9]  
Maes Michael, 1995, P933
[10]   A review of the efficacy of serotonergic and noradrenergic reuptake inhibitors for treatment of major depression [J].
Nelson, JC .
BIOLOGICAL PSYCHIATRY, 1999, 46 (09) :1301-1308