Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans

被引：88

作者：

Baker, Lorina G. ^{[1
]}

Specht, Charles A. ^{[2
]}

Lodge, Jennifer K. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Univ Massachusetts, Dept Med, Worcester, MA 01605 USA

来源：

EUKARYOTIC CELL | 2011年 / 10卷 / 09期

关键词：

FLUCONAZOLE; CHITIN; INTEGRITY;

D O I：

10.1128/EC.05138-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

引用

页码：1264 / 1268

页数：5

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