Human infection with highly pathogenic H5N1 influenza virus

被引:239
作者
Gambotto, Andrea [1 ,2 ,3 ,4 ]
Barratt-Boyes, Simon M. [5 ,6 ,7 ]
de Jong, Menno D. [8 ,9 ]
Neumann, Gabriele [10 ]
Kawaoka, Yoshihiro [10 ,11 ]
机构
[1] Univ Pittsburgh, Sch Med, Inst Mol Med, Dept Surg,Div Infect Dis, Pittsburgh, PA 15219 USA
[2] Univ Pittsburgh, Sch Med, Dept Mol Genet, Div Infect Dis, Pittsburgh, PA 15219 USA
[3] Univ Pittsburgh, Sch Med, Dept Biochem, Div Infect Dis, Pittsburgh, PA 15219 USA
[4] Univ Pittsburgh, Sch Med, Inst Mol Med, Dept Med,Div Infect Dis, Pittsburgh, PA 15219 USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA USA
[6] Univ Pittsburgh, Sch Med, Ctr Vaccine Res, Pittsburgh, PA USA
[7] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA
[8] Hosp Trop Dis, Oxford Univ Clin Res Unit, Ho Chi Minh City, Vietnam
[9] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands
[10] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA
[11] Univ Tokyo, Inst Med Sci, Tokyo, Japan
基金
英国惠康基金;
关键词
D O I
10.1016/S0140-6736(08)60627-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Highly pathogenic H5N1 influenza A viruses have spread relentlessly across the globe since 2003, and they are associated with widespread death in poultry, substantial economic loss to farmers, and reported infections of more than 300 people with a mortality rate of 60%. The high pathogenicity of H5N1 influenza viruses and their capacity for transmission from birds to human beings has raised worldwide concern about an impending human influenza pandemic similar to the notorious H1N1 Spanish influenza of 1918. Since many aspects of H5N1 influenza research are rapidly evolving, we aim in this Seminar to provide an up-to-date discussion on select topics of interest to influenza clinicians and researchers. We summarise the clinical features and diagnosis of infection and present therapeutic options for H5N1 infection of people. We also discuss ideas relating to virus transmission, host restriction, and pathogenesis. Finally, we discuss vaccine development in view of the probable importance of vaccination in pandemic control.
引用
收藏
页码:1464 / 1475
页数:12
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