Remotely triggered release from magnetic nanoparticles

被引：209

作者：

Derfus, Austin M.

von Maltzahn, Geoffrey

Harris, Todd J.

Duza, Tasmia

Vecchio, Kenneth S.

Ruoslahti, Erkki

Bhatia, Sangeeta N.

机构：

[1] MIT, Div Hlth Sci & Technol, Div Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] Brigham & Womens Hosp, Div Med, Cambridge, MA 02139 USA

[3] Burnham Inst Med Res, La Jolla, CA USA

[4] Univ Calif San Diego, Jacobs Sch Engn, Dept NanoEngn, San Diego, CA 92103 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 22期

关键词：

D O I：

10.1002/adma.200700091

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multifunctional nanoparticles are multivalent, remotely-actuated, and imaged non-invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat-labile tethers to release model drugs in vivo (see figure).

引用

收藏

页码：3932 / +

页数：6

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