Effects of five nights of normobaric hypoxia on the ventilatory responses to acute hypoxia and hypercapnia

This study examined the effects of five nights of normobaric hypoxia on ventilatory responses to acute isocapnic hypoxia (AHVR) and hyperoxic hypercapnia (AHCVR). Twelve male subjects (26.6+/-4.1 years, standard deviation (S.D.)) slept 8-9 h per day overnight for 5 consecutive days at a simulated altitude of 4300 in (FiO(2) = similar to 13.8%). Using the technique of dynamic end-tidal forcing, the AHVR and AHCVR were assessed twice prior to, immediately after, and 5 days following the hypoxic exposure. Immediately following the exposure, AHVR was increased by 1.6+/-1.3 L min(-1)%(-1) (P < 0.01) when compared with control values. Likewise, after the exposure, ventilation in hyperoxia was increased (P < 0.001) and was associated with both an increase in the slope (1.5+/-1.4 L min(-1) Torr(-1); P < 0.05) and decrease in the intercept (-2.7+/-4.3 Torr; P < 0.05) of the AHCVR. These results show that five nights of hypoxia can elicit similar perturbations, in both AHVR and AHCVR, as have been reported during more chronic altitude exposures. (C) 2003 Published by Elsevier B.V.