Lysophospholipids in the nervous system

被引：46

作者：

Chun, J ^{[1
]}

机构：

[1] Scripps Res Inst, Helen L Dorris Inst Neurol & Psychiat Disorders, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2005年 / 77卷 / 1-4期

关键词：

lysophosphatidic acid; lysophosphatidylcholine; sphingosine; 1-phosphate; neuroscience; G protein-coupled receptor; LPA; S1P;

D O I：

10.1016/j.prostaglandins.2004.09.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (SIP), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics: Signaling Lipids and Drugs of Abuse" held in Washington, D.C., 15-17 April 2004, organized by Dr. Rao Rapaka. Lysophospholipids represent one class of lipids that has many important actions mediated by G protein-coupled receptors. while influencing a large number of biologically important systems, this discussion will focus on the nervous system, including areas of future research. (c) 2004 Elsevier Inc. All rights reserved.

引用

收藏

页码：46 / 51

页数：6

相关论文

共 41 条

[1] Lysophospholipid G protein-coupled receptors [J].

Anliker, B ;

Chun, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :20555-20558

[2] The immune modulator FTY720 targets sphingosine 1-phosphate receptors [J].

Brinkmann, V ;

Davis, MD ;

Heise, CE ;

Albert, R ;

Cottens, S ;

Hof, R ;

Bruns, C ;

Prieschl, E ;

Baumruker, T ;

Hiestand, P ;

Foster, CA ;

Zollinger, M ;

Lynch, KR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21453-21457

[3]

Chun J, 2000, ANN NY ACAD SCI, V905, P110

[4] Requirement for the IpA1 lysophosphatidic acid receptor gene in normal suckling behavior [J].

Contos, JJA ;

Fukushima, N ;

Weiner, JA ;

Kaushal, D ;

Chun, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13384-13389

[5] Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia [J].

Corfas, G ;

Roy, K ;

Buxbaum, J .

NATURE NEUROSCIENCE, 2004, 7 (06) :575-580

[6] Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins [J].

Coursol, S ;

Fan, LM ;

Le Stunff, H ;

Spiegel, S ;

Gilroy, S ;

Assmann, SM .

NATURE, 2003, 423 (6940) :651-654

[7] The LPA receptors [J].

Fukushima, N ;

Chun, J .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2001, 64 (1-4) :21-32

[8] Neurobiology of lysophosphatidic acid signaling [J].

Fukushima, N ;

Ye, XQ ;

Chun, J .

NEUROSCIENTIST, 2002, 8 (06) :540-550

[9] Lysophospholipid receptors [J].

Fukushima, N ;

Ishii, I ;

Contos, JJA ;

Weiner, JA ;

Chun, J .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2001, 41 :507-534

[10] Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia [J].

Hakak, Y ;

Walker, JR ;

Li, C ;

Wong, WH ;

Davis, KL ;

Buxbaum, JD ;

Haroutunian, V ;

Fienberg, AA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4746-4751

← 1 2 3 4 5 →