Polymorphism of the human β3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function

被引：103

作者：

Hoffstedt, J

Poirier, O

Thörne, A

Lönnqvist, F

Herrmann, SM

Cambien, F

Arner, P

机构：

[1] Huddinge Univ Hosp, Dept Med, Karolinska Inst, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Dept Surg, Karolinska Inst, S-14186 Huddinge, Sweden

[3] Huddinge Univ Hosp, Res Ctr, Karolinska Inst, S-14186 Huddinge, Sweden

[4] INSERM, Paris, France

来源：

DIABETES | 1999年 / 48卷 / 01期

关键词：

D O I：

10.2337/diabetes.48.1.203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：203 / 205

页数：3

共 17 条

[1] THE BETA(3)-ADRENERGIC RECEPTOR - A CAUSE AND CURE OF OBESITY [J].

ARNER, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (06) :382-383

[2] Obesity genes [J].

Beales, PL ;

Kopelman, PG .

CLINICAL ENDOCRINOLOGY, 1996, 45 (04) :373-378

[3] Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant [J].

Candelore, MR ;

Deng, LP ;

Tota, LM ;

Kelly, LJ ;

Cascieri, MA ;

Strader, CD .

ENDOCRINOLOGY, 1996, 137 (06) :2638-2641

[4] Role of the beta(3)-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair [J].

Elbein, SC ;

Hoffman, M ;

Barrett, K ;

Wegner, K ;

Miles, C ;

Bachman, K ;

Berkowitz, D ;

Shuldiner, AR ;

Leppert, MF ;

Hasstedt, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12) :4422-4427

[5] The Trp64Arg mutation of the beta 3 adrenergic receptor gene has no effect on obesity phenotypes in the Quebec family study and Swedish obese subjects cohorts [J].

Gagnon, J ;

Mauriege, P ;

Roy, S ;

Sjostrom, D ;

Chagnon, YC ;

Dionne, FT ;

Oppert, JM ;

Perusse, L ;

Sjostrom, L ;

Bouchard, C .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (09) :2086-2093

[6] A MUTATION IN THE BETA(3)-ADRENERGIC RECEPTOR GENE IS ASSOCIATED WITH OBESITY AND HYPERINSULINEMIA IN JAPANESE SUBJECTS [J].

KADOWAKI, H ;

YASUDA, K ;

IWAMOTO, K ;

OTABE, S ;

SHIMOKAWA, K ;

SILVER, K ;

WALSTON, J ;

YOSHINAGA, H ;

KOSAKA, K ;

YAMADA, N ;

SAITO, Y ;

HAGURA, R ;

AKANUMA, Y ;

SHULDINER, A ;

YAZAKI, Y ;

KADOWAKI, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 215 (02) :555-560

[7] A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride [J].

KimMotoyama, H ;

Yasuda, K ;

Yamaguchi, T ;

Yamada, N ;

Katakura, T ;

Shuldiner, AR ;

Akanuma, Y ;

Ohashi, Y ;

Yazaki, Y ;

Kadowaki, T .

DIABETOLOGIA, 1997, 40 (04) :469-472

[8] The beta 3-adrenergic receptor gene Trp64Arg mutation is overrepresented in obese women - Effects on weight, BMI, abdominal fat, blood pressure, and reproductive history in an elderly Australian population [J].

Kurabayashi, T ;

Carey, DGP ;

Morrison, NA .

DIABETES, 1996, 45 (10) :1358-1363

[9] Phenotypic characterization of the Trp64Arg polymorphism in the beta(3)-adrenergic receptor gene in normal weight and obese subjects [J].

Li, LS ;

Lonnqvist, F ;

Luthman, H ;

Arner, P .

DIABETOLOGIA, 1996, 39 (07) :857-860

[10] Trp64Arg substitution in the beta(3)-adrenergic receptor does not relate to body weight in healthy, premenopausal women [J].

Moriarty, M ;

Wing, RR ;

Kuller, LH ;

Ferrell, RE .

INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (09) :826-829

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