Predicting specificity in bZIP coiled-coil protein interactions

被引：91

作者：

Fong, JH

Keating, AE

Singh, M

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Princeton Univ, Dept Comp Sci, Princeton, NJ 08544 USA

[3] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1186/gb-2004-5-2-r11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performance. Our method can be used to predict bZIP interactions in other genomes and is a promising approach for predicting coiled-coil interactions more generally.

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页数：10

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