Structure and function of argonaute proteins

被引：90

作者：

Hall, TMT ^{[1
]}

机构：

[1] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

STRUCTURE | 2005年 / 13卷 / 10期

关键词：

D O I：

10.1016/j.str.2005.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Argonaute (Ago) family proteins are multidomain proteins expressed in prokaryotic and eukaryotic organisms. In eukaryotes, Ago proteins are most well known for their roles in RNA silencing. In prokaryotes, the functions of Ago proteins are unknown, but based on their similarity to eukaryotic Ago proteins, they could be involved in nucleic acid-directed regulatory pathways related to RNA silencing. Recent structural and biochemical studies have shed new light on the function of this family of proteins. These studies reveal how these proteins recognize and cleave RNA and suggest a function for prokaryotic family members.

引用

页码：1403 / 1408

页数：6

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