Osteopontin identified as colon cancer tumor progression marker

被引：41

作者：

Agrawal, D

Chen, T

Irby, R

Quackenbush, J

Chambers, AF

Szabo, M

Cantor, A

Coppola, D

Yeatman, TJ ^{[1
]}

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Surg, Tampa, FL 33682 USA

[2] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Pathol, Tampa, FL 33682 USA

[3] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Cell Biol, Tampa, FL 33682 USA

[4] Inst Genomic Res, Rockville, MD USA

[5] Univ Western Ontario, London Reg Canc Ctr, London, ON, Canada

[6] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Biostat & Interdisciplinary Oncol, Tampa, FL 33682 USA

来源：

COMPTES RENDUS BIOLOGIES | 2003年 / 326卷 / 10-11期

关键词：

colon cancer; microarray; osteopontin;

D O I：

10.1016/j.crvi.2003.09.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved.

引用

页码：1041 / 1043

页数：3

共 4 条

[1]

Agrawal D, 2002, J NATL CANCER I, V94, P513

[2] Cluster analysis and display of genome-wide expression patterns [J].