Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses

被引：527

作者：

Fox, MD ^{[1
]}

Snyder, AZ

Zacks, JM

Raichle, ME

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Neurol, St Louis, MO 63110 USA

[3] Washington Univ, Dept Psychol, St Louis, MO 63110 USA

[4] Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63110 USA

[5] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 01期

关键词：

D O I：

10.1038/nn1616

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity account for a significant fraction of the variability in measured event-related BOLD responses and that spontaneous and task-related activity are linearly superimposed in the human brain.

引用

页码：23 / 25

页数：3

共 15 条

[1] Dynamics of ongoing activity: Explanation of the large variability in evoked cortical responses
Arieli, A
Sterkin, A
Grinvald, A
Aertsen, A
[J]. SCIENCE, 1996, 273 (5283) : 1868 - 1871
[2] Azouz R, 1999, J NEUROSCI, V19, P2209
[3] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI
BISWAL, B
YETKIN, FZ
HAUGHTON, VM
HYDE, JS
[J]. MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) : 537 - 541
[4] Cordes D, 2000, AM J NEURORADIOL, V21, P1636
[5] Small modulation of ongoing cortical dynamics by sensory input during natural vision
Fiser, J
Chiu, CY
Weliky, M
[J]. NATURE, 2004, 431 (7008) : 573 - 578
[6] The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, MD
Snyder, AZ
Vincent, JL
Corbetta, M
Van Essen, DC
Raichle, ME
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) : 9673 - 9678
[7] Detection of functional connectivity using temporal correlations in MR images
Hampson, M
Peterson, BS
Skudlarski, P
Gatenby, JC
Gore, JC
[J]. HUMAN BRAIN MAPPING, 2002, 15 (04) : 247 - 262
[8] Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations
Lowe, MJ
Mock, BJ
Sorenson, JA
[J]. NEUROIMAGE, 1998, 7 (02) : 119 - 132
[9] Olshausen B. A., 2003, The Visual Neurosciences, V2, P1603
[10] Quantitative prediction of perceptual decisions during near-threshold fear detection
Pessoa, L
Padmala, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (15) : 5612 - 5617

← 1 2 →