Assembly of microarrays for genome-wide measurement of DNA copy number.

被引：673

作者：

Snijders, AM

Nowak, N

Segraves, R

Blackwood, S

Brown, N

Conroy, J

Hamilton, G

Hindle, AK

Huey, B

Kimura, K

Law, S

Myambo, K

Palmer, J

Ylstra, B

Yue, JP

Gray, JW

Jain, AN

Pinkel, D

Albertson, DG ^{[1
]}

机构：

[1] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[4] New York State Dept Hlth, Roswell Pk Canc Inst, Buffalo, NY 14263 USA

来源：

NATURE GENETICS | 2001年 / 29卷 / 03期

关键词：

D O I：

10.1038/ng754

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log(2) ratios=0.05-0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.

引用

页码：263 / 264

页数：2

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