Myostatin as a therapeutic target for musculoskeletal disease

被引：55

作者：

Bradley, L. ^{[2
]}

Yaworsky, P. J. ^{[2
]}

Walsh, F. S. ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Collegeville, PA 19426 USA

[2] Wyeth Ayerst Res, Discovery Res, Cambridge, MA 02140 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 14期

关键词：

muscle; myostatin; muscular dystrophy; sarcopenia; amyotrophic lateral sclerosis;

D O I：

10.1007/s00018-008-8077-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

引用

收藏

页码：2119 / 2124

页数：6

相关论文

共 33 条

[1]

Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis [J].

Amthor, H ;

Nicholas, G ;

McKinnell, I ;

Kemp, CF ;

Sharma, M ;

Kambadur, R ;

Patel, K .

DEVELOPMENTAL BIOLOGY, 2004, 270 (01) :19-30

[2]

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle [J].

Anderson, Sarah B. ;

Goldberg, Alfred L. ;

Whitman, Malcolm .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (11) :7027-7035

[3]

AAV-mediated delivery of a mutated myostatin propeptide ameliorates calpain 3 but not α-sarcoglycan deficiency [J].

Bartoli, M. ;

Poupiot, J. ;

Vulin, A. ;

Fougerousse, F. ;

Arandel, L. ;

Daniele, N. ;

Roudaut, C. ;

Noulet, F. ;

Garcia, L. ;

Danos, O. ;

Richard, I. .

GENE THERAPY, 2007, 14 (09) :733-740

[4]

Functional improvement of dystrophic muscle by myostatin blockade [J].

Bogdanovich, S ;

Krag, TOB ;

Barton, ER ;

Morris, LD ;

Whittemore, LA ;

Ahima, RS ;

Khurana, TS .

NATURE, 2002, 420 (6914) :418-421

[5]

Myostatin propeptide-mediated amelioration of dystrophic pathophysiology [J].

Bogdanovich, S ;

Perkins, KJ ;

Krag, TOB ;

Whittemore, SA ;

Khurana, TS .

FASEB JOURNAL, 2005, 19 (06) :543-549

[6]

Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C [J].

Bogdanovich, Sasha ;

Mcnally, Elizabeth M. ;

Khurana, Tejvir S. .

MUSCLE & NERVE, 2008, 37 (03) :308-316

[7]

Myostatin polymorphisms and age-related sarcopenia in the Italian population [J].

Corsi, AM ;

Ferrucci, L ;

Gozzini, A ;

Tanini, A ;

Brandi, ML .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (08) :1463-1463

[8]

Myostatin auto-regulates its expression by feedback loop through Smad7 dependent mechanism [J].

Forbes, D ;

Jàckman, M ;

Bishop, A ;

Thomas, M ;

Kambadur, R ;

Sharma, M .

JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 206 (01) :264-272

[9]

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors [J].

Haidet, Amanda M. ;

Rizo, Liza ;

Handy, Chalonda ;

Umapathi, Priya ;

Eagle, Amy ;

Shilling, Chris ;

Boue, Daniel ;

Martin, Paul T. ;

Sahenk, Zarife ;

Mendell, Jerry R. ;

Kaspar, Brian K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (11) :4318-4322

[10]

The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum [J].

Hill, JJ ;

Davies, MV ;

Pearson, AA ;

Wang, JH ;

Hewick, RM ;

Wolfman, NM ;

Qiu, YC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (43) :40735-40741

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