Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis

被引：55

作者：

Battinelli, Elisabeth M.

Hartwig, John H.

Italiano, Joseph E., Jr.

机构：

[1] Brigham & Womens Hosp, Translat Med Div, Dept Med, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Dept Hematol & Oncol, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Childrens Hosp, Vasc Biol Program, Dept Surg, Boston, MA 02115 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2007年 / 14卷 / 05期

关键词：

megakaryocyte; platelet; proplatelet;

D O I：

10.1097/MOH.0b013e3282bad151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The aim of this review is to explore the state of the art knowledge on the cell biological and molecular pathways that regulate megakaryopoiesis and lead to platelet production. Recent findings In the last 2 years there has been considerable progress in the elucidation of molecular mechanisms of megakryocyte development and platelet biogenesis, driven by, the application of modern molecular biology approaches to these specialized and unique cells. Studies have for the first time visualized endomitotic spindle dynamics, characterized the maturation of the demarcation membrane system, and delineated the mechanics of organelle transport and microtubule assembly in living megakaryocytes. The role of specific molecules in platelet production has been elucidated in greater detail by combining molecular studies with genetically engineered mice as well as embryonic,cell culture systems. Summary This review integrates the latest studies of megakaryocyte development into the molecular pathways that regulate megakaryopoiesis and thrombopoiesis, pathways of megakaryopoiesis and p should help, revolutionize the management of thrombocytopenia and other platelet disorders.

引用

页码：419 / 426

页数：8

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