Symptoms of spinal stenosis do not improve after epidural steroid injection

被引:137
作者
Fukusaki, M
Kobayashi, I
Hara, T
Sumikawa, K
机构
[1] Nagasaki Rosai Hosp, Dept Anesthesia, Nagasaki 85701, Japan
[2] Nagasaki Univ, Sch Med, Dept Anesthesiol, Nagasaki 852, Japan
关键词
lumbal; epidural steroid; pseudoclaudication; spinal canal stenosis;
D O I
10.1097/00002508-199806000-00010
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Objective: This study was carried out to evaluate the therapeutic effect of epidural steroid injection on pseudoclaudication in patients with lumbar degenerative spinal canal stenosis. Design: Fifty-three patients who complained of pseudoclaudication of less than 20 m in walking distance were randomly divided into three groups. Group 1 (n = 16) underwent epidural injection with 8 ml of saline. Group 2 (n = 18) underwent epidural block with 8 ml of 1% mepivacaine. Group 3 (n = 19) underwent epidural block with a combination of 8 ml of 1% mepivacaine and 40 mg of methylprednisolone. The criteria of evaluation were as follows: excellent effect, >100 m in walking distance; good effect, 20-100 m in walking distance; poor effect, <20 m in walking distance. Results: In group 1, the numbers of patients who showed a good effect were two (12.5%) after 1 week, one (6.5%) after 1 month, and one (6.5%) after 3 months. In group 2, the numbers of patients who showed a good or excellent result were 10 (55.5%) after 1 week, three (16.7%) after 1 month, and one (5.6%) after 3 months. In group 3, the numbers of patients who showed a good or excellent result were 12 (63.2%) after 1 week, three (15.8%) after 1 month, and one (5.3%) after 3 months. There was no significant difference in the effectiveness of treatment between group 2 and group 3 throughout the time course. Conclusion: The results suggest that epidural steroid injection has no beneficial effect on the pseudoclaudication associated with spinal canal stenosis as compared with epidural block with a local anesthetic alone.
引用
收藏
页码:148 / 151
页数:4
相关论文
共 25 条
[1]   ANALGESIC AND NEUROTOXIC EFFECTS OF INTRATHECAL CORTICOSTEROIDS IN RATS [J].
ABRAM, SE ;
MARSALA, M ;
YAKSH, TL .
ANESTHESIOLOGY, 1994, 81 (05) :1198-1205
[2]  
BLAU JN, 1961, LANCET, V1, P1081
[3]  
BREVIK H, 1976, ADV PAIN RES THER, V1, P927
[4]   CONTRIBUTION OF PROTEIN-KINASE-C TO CENTRAL SENSITIZATION AND PERSISTENT PAIN FOLLOWING TISSUE-INJURY [J].
CODERRE, TJ .
NEUROSCIENCE LETTERS, 1992, 140 (02) :181-184
[5]   MORBIDITY AND MORTALITY IN ASSOCIATION WITH OPERATIONS ON THE LUMBAR SPINE - THE INFLUENCE OF AGE, DIAGNOSIS, AND PROCEDURE [J].
DEYO, RA ;
CHERKIN, DC ;
LOESER, JD ;
BIGOS, SJ ;
CIOL, MA .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1992, 74A (04) :536-543
[6]   EXTRADURAL CORTICOSTEROID INJECTION IN MANAGEMENT OF LUMBAR NERVE ROOT COMPRESSION [J].
DILKE, TFW ;
BURRY, HC ;
GRAHAME, R .
BRITISH MEDICAL JOURNAL, 1973, 2 (5867) :635-637
[7]  
DIROSA M, 1986, AGENTS ACTIONS, V17, P284
[8]  
EVANS JG, 1964, BMJ-BRIT MED J, V2, P295
[9]   BIOLOGY OF PLACEBO ANALGESIA [J].
FIELDS, HL ;
LEVINE, JD .
AMERICAN JOURNAL OF MEDICINE, 1981, 70 (04) :745-746
[10]  
Fukusaki M, 1995, PAIN CLINIC, V8, P219