Synthesis and antimicrobial activity of some new benzimidazole derivatives

被引：326

作者：

El-masry, AH ^{[1
]}

Fahmy, HH ^{[1
]}

Abdelwahed, SHA ^{[1
]}

机构：

[1] Natl Res Ctr, Therapeut Chem Dept, Cairo, Egypt

来源：

MOLECULES | 2000年 / 5卷 / 12期

关键词：

methylbenzimidazole; oxadiazole; thioglycolic; thiolactic; triazole; pyrazole; antimicrobial;

D O I：

10.3390/51201429

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities.

引用

页码：1429 / 1438

页数：10

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